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Morgellons Syndrome: A Programmed Matrix System

by Kathryn Augustyn and Kandy Griffin
Morgellons Research Group
December 2, 2012

[Potent News Editor’s note: click here to see an archived version of this article which includes some of the pictures that are missing in this version.]

Morgellons Syndrome: A Programmed Matrix System

Part I

An Ecological Environmental Evolution is facing humanity today.  Many citizens are beginning to see the changes in the environment, in the air, water, land mass and in living organisms.  Many plant/tree wilt diseases are giving us clues, but we still cannot believe that plants, trees and insects have and do carry viruses and pheromones that recognize their preys in humans by scent. Many people with Morgellons first noticed some type of bug bite or what felt like a bug bite.   These bugs often fly at our faces, they recognize a prey pheromone in us.  That means universal pheromone proteins, non coding RNA, or promoter, reporter, or induction gene similar to its prey, so when bit, even more DNA is dumped into our bodies.  This begins a pathological type condition that is typical of Morgellons.

MRG, in general, believes that Morgellons syndrome involves five criteria that are present in the symptoms and are seen in many images and petri dishes.  This involves Spheres, Filaments, (including a conducting filament, plus other sizes); Hexagons, a BioFilm and an Organism.

In more detail, we have narrowed down some descriptions and the  most current information available.  Morgellons was created in labs around the world, released into the environment, thereby modifying the human genome.  This was done through GMO foods, artificial sugars, flavors, colors, geoengineering, university field releases, pharma field releases, herbicides, pesticides and transgenic wildlife, evolutionary experiments and use of transposon mobile genetic elements.  This has altered and/or killed trees, plants, animals and humans.  This along with heat shock proteins have provided capacitors for adaptation and selection of living organisms to either cooperate, face the painful consequences, or cheat the new paradigm.  This is Human Bionano Technical Tyranny.

Our five criteria are:

1.Sphere, Particles (RNA protocell) forms the guiding RNA. Dark matter and melanin. Protocell from Bacteria/Eukaryota/Archaea and/or artificial/synthetic material hybridize to human cells/chromosomes/histones, Quantum dot particles/metalloid nanoparticles.

2. Filaments (CB001) cyanobacteria or PNAs (glycine). Short Telechelic Polymers connect the network, carries the protocells or quantum dots for signals. (a). colored filaments, (protofibrils developed from monomers, amphiphiles and bolamphiphiles) can be sensors and trackers). Nanowires, Nanotubes and Polymers can form smaller filaments. 

3. Hexagons (crystallized forms or crystallized proteins from sphere monomer) which form dimers (2 hexs etc) are part of the formation of the filaments)  and crystallized protein or alloprotein metalloids can be present in these forms. 

4. Biofilm (agrobacterium-like gall) can form a callous, possibly fungal/yeast/slime/rhizoid/algae filamentous structure in connection with an embryo/spore forming gymnosperm or angiosperm.

5. Organism (FL1953 Protomyxzoa)  lives under the filamentous biofilm, a form created by the filamentous structures and contact with mucous and fluids in the human body.  Using the human as symbiotic host.  Pleomorphism or morphology of biological/inorganic forms.

We are concentrating on the spheres and the filaments.  Researchers have sent specimens to Labs for fungal identification and those have been reviewed.  .  This includes fusarium, aspergillis, cladosporium, and other fungi.  However, this seems to be a cofactor in the Morgellons Syndrome manifestation.  We have sent a Protozoan-like specimen to a lab, and this could not be identified as any known protozoan.  We have had hexagons analyzed showing chlorine and oxygen and metalloid hexagons as well showing iridium, antimony and other metals.

We have found information on protocells and how they were created.  RNA protocells seem to be the spheres.   We will begin with types of Protocells.  Below are requirements for protocells”

The Origins of Cellular Life

“Understanding the origin of cellular life on Earth requires the discovery of plausible pathways for the transition from complex prebiotic chemistry to simple biology, defined as the emergence of chemical assemblies capable of Darwinian evolution. We have proposed that a simple primitive cell, or protocell, would consist of two key components: a protocell membrane that defines a spatially localized compartment, and an informational polymer that allows for the replication and inheritance of functional information”………..

Recent studies of vesicles composed of fatty-acid membranes have shed considerable light on pathways for protocell growth and division, as well as means by which protocells could take up nutrients from their environment. Additional work with genetic polymers has provided insight into the potential for chemical genome replication and compatibility with membrane encapsulation. The integration of a dynamic fatty-acid compartment with robust, generalized genetic polymer replication would yield a laboratory model of a protocell with the potential for classical Darwinian biological evolution, and may help to evaluate potential pathways for the emergence of life on the early Earth. Here we discuss efforts to devise such an integrated protocell model.       http://cshperspectives.cshlp.org/content/2/9/a002212.long

Attempts have been made to solve the initial protocell of life,  however, these protocells are becoming part of the environment, today, as if a new evolutionary direction is being taken to bring in the artificial protocell of RNA to be used for an “autonomous adaptive system” within the Extracellular Matrix in the human body.  Why such a request for a “protocell”?  They have been created. Many with Morgellons have what is called “pseudovesicles” which most likely are biofilms that calcify and make callouses.  These callouses are both inorganic and organic.

These vesicles self assemle and form Protocells.  These can group together, under skin forming a new vesicle which can be called a ‘pseudovesicle” or false vesicle.   Once the protocell is formed, the information carried is transferred to the system.  And these protocells can replicate.   The amphiphiles are in layers.  The vesicles self assemble into protocells. They cluster or separate by repulsion or attraction to water.  It appears that the amphiphiles and vesicles work together to form the protocell cluster which can be altered by EM, RF or possibly light wave.  In the image one can see where inorganic and organic forms become part of the protocell.  Fatty acids are important in the formation of the vesicles, which have been seen on Morgellon’s sufferers as small white pearly bumps.  Some are red as these vesicles push other cells out of the way.  These vesicles grow and accumulate in protocells forming the biofilm like structures.

From Self-Assembled Vesicles to Protocells

Self-assembled vesicles are essential components of primitive cells. We review the importance of vesicles during the origins of life, fundamental thermodynamics and kinetics of self-assembly, and experimental models of simple vesicles, focusing on prebiotically plausible fatty acids and their derivatives. We review recent work on interactions of simple vesicles with RNA and other studies of the transition from vesicles to protocells. Finally we discuss current challenges in understanding the biophysics of protocells, as well as conceptual questions in information transmission and self-replication.

For synthetic biologists, a useful operational definition of life is “a self-sustaining chemical system capable of Darwinian evolution,” which was adopted by the Exobiology program of NASA (Joyce 1994). In the quest to build a simple living system, much recent interest has focused on encapsulating a genetic or metabolic system inside membrane vesicles (Deamer and Dworkin 2005; Luisi et al. 1999; Morowitz et al. 1988; Ourisson and Nakatani 1994; Szostak et al. 2001). Vesicles are supramolecular aggregates containing an aqueous interior that is separated from the bulk solution by one or more bilayers of amphiphiles.

Thermodynamics of Self-Assembly of Amphiphiles

Self-assembled structures of amphiphiles are the result of a balance of attractive and repulsive forces. Amphiphiles tend to aggregate because of the hydrophobic effect, which stems primarily from the strong attraction of water for itself (Tanford 1973). Nonpolar solutes disrupt the isotropic hydrogen bonding of water, causing an entropic loss at the solute-water interface. Therefore nonpolar molecules tend to aggregate to minimize the interface (direct attractive interactions, such as van der Waals forces, play a relatively small role). In the absence of a repulsive force, the hydrophobic effect would lead to bulk-phase separation. However, repulsion among amphiphiles resulting from sterics (e.g., among hydrated head groups) or electrostatics favors the formation of structured assemblages.

Structures of prebiotically plausible single chain amphiphiles and a commonly used buffer. (A) micelle; (B) vesicle; (C) myristoleic acid; (D) bicine; (E) geranylgeranyl phosphoric acid; (F) n-decylphosphonic acid.

These protocells we believe have been released into the environment.  A forced/adaptive non coding RNA protocell to reverse transcriptase and control the human genome involves Epigenetics.   This is being done by glycosylation, ubiquination, acetylation, phosphorylation and methylation.  This can be called Transformation, or “survival of the fittest”.   However, the down side is the consequences.  Morgellons Syndrome is one of the consequences.  In every forced/directed evolution, there are casualties.  These can happen fast, not like the so-called evolutionary concept.  Below is an article describing protocells made from lipids and takes us into the molecular world.  Humans have lipids.

Model Protocells from Single-Chain Lipids

Membranes are important cellular constituents, allowing for processes such as ATP synthesis and neurochemical signal-transduction. Due to the long evolutionary history of cellular membranes, they are highly complex assemblies consisting primarily of double-chain lipids, sterols, and transmembrane spanning proteins. This level of complexity is necessary to create an impermeable barrier that allows for both the generation of electrochemical gradients and for the specific transfer of molecules across the membrane. In other words, contemporary cells are capable of maintaining a strong barrier between their internal contents and the extracellular space while retaining the ability to specifically absorb or release desired molecules through the use of transmembrane spanning proteins. The result is an asymmetric, nonequilibrium distribution of molecules that can be harnessed for physiological purposes. Clearly, Earth’s first cell-like structures did not already posses such complexity. Instead, more simple membrane systems likely existed that exhibited many of the characteristics that modern biological membranes possess without relying on genetically encoded transport systems.”

Lipid dynamics. a) Exchange of lipids between different aggregate structures, including micelles (left), free monomers (center), and vesicles (right) b) Lipid flip-flop between inner- and outer-leaflets of a bilayer membrane.
Many researchers have questioned the use of protocells, today.  What is the purpose? Finding the basis of the cell at the beginning of life is one thing, but there is concern over the use of the synthetic forms and even the biological forms.

“Protocells are tiny, self-organizing, evolving entities that spontaneously assemble
and continuously regenerate themselves from simple organic and inorganic sub-
strates in their environment. A number of scientific teams around the world are
racing to create protocells, and success is expected within a few years.
Protocells will raise a number of social and ethical issues, involving benefits to
individuals and to society, risks to human health and the environment, and trans-
gressions of cultural and moral prohibitions. This volume contains the thoughts of
a diverse group of experts who explore the prospect of protocells from a variety of
perspectives. These perspectives include applied ethics in analytical philosophy,
continental philosophy, and anthropology as well as political and social commen-
tary. The book raises broad questions for a broad audience, without necessarily
drawing final conclusions……..

……….

The creation of fully autonomous protocells is only a matter of
time.
Protocells are capturing growing public attention. New companies for creating
artificial life forms are now being created in Europe and America,
and the commercial and scientific advances are attracting increasing media attention.
The increasing pace of breakthroughs in protocell science will increasingly heighten
public interest in their broader implications.
The prospect of creating protocells raises some pressing social and ethical issues.
Protocells will offer new benefits to individuals and to society and vast new eco-
nomic opportunities, but they also have the potential to pose risks to human health
and the environment, as well as to transgress cultural and moral norms.

Because protocells are living matter created from nonliving matter, they will be unlike any
previous technology humans have created, and their development will take society
into uncharted waters. This book aims to inform interested parties about these new
developments and to promote an open and responsible process of evaluating the
prospect of protocells………..

http://www.wosco.org/books/Philosophy/EthicsProtocells.pdf

One has to wonder just who these stakeholders are, in the creation of these protocells, as in the Morgellons Study done by the CDC.

We have found in Morgellons sufferers DNA/cell/chromosome/histone damage. Some people have severe skin damage, much scarring, and we do have “pseudovesicles”. We have dimers, we have scarred blood cells and many are losing blood cells.  We have forms that should not appear in humans.  We have clawed forms, tubes within tubes, telechelic polymers and filaments wrapped around fat cells.  We have abdominal swelling from filaments clustered in the abdomen. Twisted colons pushing up into the diaphram have required surgery.  There are left handed DNA present in descendents of those with initial stages of Morgellons.  Babies are born with Morgellons.  Many people have died from Morgellons.

One of our researchers found where all of a sudden the discovery of AEG in Cyanobacteria has caused surprise in the Scientific Community.  Why should it?  This AEG has been synthesized, already.  When real science is shown, then those who have already created synthetic life from the lab, are surprised.  Was the deed uncovered?  Please read and judge for yourself.  From our studies cyanobacteria was used in the model for human multicellular protocell or minimal cell creation.

http://www.sciencedaily.com/releases/2012/11/121110093550.htm

Cyanobacteria Produce N-(2-Aminoethyl)Glycine, a Backbone for Peptide Nucleic Acids …….

In looking for what the spheres present in Morgellon lesions are, we come close to identifying them as “protocells” or vesicles.  For scientist to find that AEG is in cyanobacteria, then, something is amiss.   When we find that AEG or N-(2Aminoethyl) Glycine which makes Peptide Nucleic Acids or PNAs then we know that these were made in lab from chemicals, a synthetic form.  So, did evolution happen as is described? Or is it being put in process now?   It appears that human Intermediate filaments, microfilaments and microtubules are being reprocessed into synthetic material or inorganic material.  This means by not informing the public of the real fossils found of previous life on the planet speculating scientists created their own scenarios, theories and hypotheses.  So, to publish papers that have no merit, declaring possible intermediates that could have existed or not, was based on what was called a theory, not proven, so as to create what would could be said to have existed in evolutionary times.   The proof is in the cyanobacteria.  Always has been, but no LUCA (last universal common ancestor) was ever established, because there was none.

So, cyanobacteria CB001 was used in the construction of the Morgellon protocell.  This protocell would be claimed to have existed before. This is not acceptable.  We know it was created in the lab.  Images here show the microsphere or the “protocell”.  These are spontaneous and if released even with “field studies” or by aerosol operations, this has changed the environment, thereby changing the human species.  Insects are affected, plants are affected and the entire microbial community.  Biofilms are forming everywhere.  Humans, animals and plants cannot escape the universal onslaught of these protocells, which now have become microbots as well.  The self-sustained replicating enzyme was identified:

“Relatively short RNA molecules have been artificially produced in labs, which are capable of replication. Such replicase RNA, which functions as both code and catalyst provides its own template upon which copying can occur. Jack Szostak has shown that certain catalytic RNAs can, indeed, join smaller RNA sequences together, creating the potential, in the right conditions for self-replication. If these conditions were present, Darwinian selection would favour the proliferation of such self-catalysing structures, to which further functionalities could be added. Lincoln and Joyce have identified an RNA enzyme capable of self-sustained replication.

https://en.wikipedia.org/wiki/Protocell#From_organic_molecules_to_protocells

This shows, you do not need biology:

An RNA enzyme that catalyzes the RNA-templated joining of RNA was converted to a format whereby two enzymes catalyze each other’s synthesis from a total of four oligonucleotide substrates. These cross-replicating RNA enzymes undergo self-sustained exponential amplification in the absence of proteins or other biological materials. Amplification occurs with a doubling time of about 1 hour and can be continued indefinitely. Populations of various cross-replicating enzymes were constructed and allowed to compete for a common pool of substrates, during which recombinant replicators arose and grew to dominate the population. These replicating RNA enzymes can serve as an experimental model of a genetic system. Many such model systems could be constructed, allowing different selective outcomes to be related to the underlying properties of the genetic system.

https://www.ncbi.nlm.nih.gov/pubmed/19131595

A self-replicating molecule directs the covalent assembly of component molecules to form a product that is of identical composition to the parent. When the newly formed product also is able to direct the assembly of product molecules, the self-replicating system can be termed autocatalytic. A self-replicating system was developed based on a ribozyme that catalyzes the assembly of additional copies of itself through an RNA-catalyzed RNA ligation reaction. The R3C ligase ribozyme was redesigned so that it would ligate two substrates to generate an exact copy of itself, which then would behave in a similar manner. This self-replicating system depends on the catalytic nature of the RNA for the generation of copies. A linear dependence was observed between the initial rate of formation of new copies and the starting concentration of ribozyme, consistent with exponential growth. The autocatalytic rate constant was 0.011 min(-1), whereas the initial rate of reaction in the absence of pre-existing ribozyme was only 3.3 x 10(-11) M.min(-1). Exponential growth was limited, however, because newly formed ribozyme molecules had greater difficulty forming a productive complex with the two substrates. Further optimization of the system may lead to the sustained exponential growth of ribozymes that undergo self-replication.

https://www.ncbi.nlm.nih.gov/pubmed/12239349

Sidney Fox called them proteinoid microspheres, protocells or protonerves.

Table 1. Salient Properties of Proteinoid Microspheres

Protobiochemical
Esterolytic
Phosphatatic
Decarboxylatic
Peroxidatic
Synthetic, with P-O-P or ATP
For peptides
For polynucleotides
Photodecarboxylatic

Protophysiological
Electrotactic
Protometabolic (Catalytic)
Aggregative
Protomobile
Osmotic
Permselective
Fissive
Protoreproductive
Conjugative
Protocommunicative
Excitable

http://asa.chm.colostate.edu/archive/evolution/199905/0001.html

Protocell Images

Image credits:  http://www.theharbinger.org/articles/rel_sci/fox.html

Below is an article on PNAs, or PNA Oligomers which are used for “gene silencing”.  These were created before the news came out about, how life began with cyanobacteria.  So, we are seeing the creation of synthetics while the real beginning of life is never really debated, only covered up until the synthetics can be created, and then will be said to have evolved from the orgins so declared.  It is like putting the “cart in front of the horse”.  
A ‘retro-inverso’ PNA: structural implications for DNA and RNA binding.

Abstract

‘Retro-inverso’ peptide nucleic acid (PNA) monomers of thymine (T*: N-(amidomethyl)-N-(N1-thyminyl-acetyl)-beta-alanyl) (and adenine) have been prepared and introduced in PNA oligomers. A homo ‘retro-inverso’ T*8 PNA was found not to hybridize to a complementary DNA or RNA oligonucleotide, whereas introduction of one retro-inverso thymine unit into the middle of a normal PNA 15-mer resulted in a c.a. 8 degrees C destabilization of the complex of this oligomer with a complementary DNA or RNA oligomer. In an effort to compensate for the structural nucleobase ‘phase-shift’ caused by the T* monomer by also introducing a beta-alanine monomer it is concluded that the effect of the T* backbone is -7 degrees C when hybridizing to DNA and -4.5 degrees C when hybridizing to RNA. Nonetheless, the T* unit shows good sequence discrimination comparable to that of normal PNA. Molecular dynamics simulations indicate an unfavourable conformation of the backbone amide carbonyl group resulting in reduced interaction with the aqueous medium and an ‘electrostatic clash’ with the carbonyl of the nucleobase linker. These results show that a simple inversion of an amide bond in the PNA backbone has a dramatic, and hardly predictable, effect on the DNA mimicking properties of the oligomer.

http://www.ncbi.nlm.nih.gov/pubmed/9881091

 And it appears the sneaky way of altering/modifying/changing DNA is through the “back door” of the  “DNA, RNA, Protein” Central Dogma.  So, create the Protein, on a non-coding RNAse polymer, then connect to the RNA, and then eventually to DNA.  However, in this case a non protein is being created, called “alloprotein”.
 ”An alloprotein is a novel syntheticprotein containing one or more “non-natural” amino acids. http://en.wikipedia.org/wiki/Alloprotein
In the expansion of the genetic code, 3 new amino acids have been added to our original 20.  These are: Selenocysteine, Prrolysine and Phenylalanine.   These involve a directed/forced evolution where man has to adapt or cheat the adaption.  Morgies are rejecting the adaptation, but are paying the price.  Are these the debris left from the experiments or are they truly created new life forms for directed/forced evolution?  I believe the integration of these forms are to be part of the new transformed human.  Some will make it, others will not.  However the cheaters may win.  We may cheat the system, if we concentrate and focus on what is in front of us.   In Part II, we will go into detail, as to how the 3 new amino acids have integrated the genome.   We continue to look for the specific characteristics of the specimens and are calling for labs to assist us in recognizing the products used to create these artefacts. 
by
Kathryn Augustyn and Kandy Griffin
MRG Researchers
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